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Sildenafil relaxes muscles and increases blood flow to particular areas of the body.

Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.
Pharmacodynamics

Pharmacokinetics

Sildenafil inhibits phosphodiesterase type-5 (PDE5) which is responsible for cGMP degradation in the corpus cavernosum. Inhibition of PDE5 increases cGMP levels in the corpus cavernosum which results in smooth muscle relaxation and inflow of blood to the corpus cavernosum.

Absorption
Rapidly absorbed after oral admin. Bioavailability: about 40%.

Distribution
Widely distributed. Plasma protein binding: 96%.

Metabolism
Metabolised in the liver mainly by CYP3A4 and CYP2C9.

Excretion
Excreted as metabolites mainly in the faeces.
Sildenafil Indications / Sildenafil Uses

Information Not Available
Sildenafil Adverse Reactions / Sildenafil Side Effects

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The most common (80%) found asymptomatic forms of prostatitis are identified by a special examination. Pain often manifests feelings of discomfort, usually localized in the suprapubic, groin, perineum, testicles. Sometimes there may be a burning sensation in the perineum, pain during urination, during and after intercourse. Disuric syndrome is characterized by more frequent and difficulty in urination, lethargy, and thinning of the urine stream. Sexual disorders are characterized by early ejaculation, weak erection, decreased sexual desire. Many patients are concerned about painful erections and orgasms, and the "blurring of orgasm." Complications of prostatitis are impotence and infertility. It is better to start taking medications like Abra with the first signs of erection problems. Abra will help on different stages, but the sooner you start treatment, the better results will be.

Frigidity (frigidity) - is a complete absence or reduction of a woman's sexual desire, specific sexual sensations and orgasm. Frigidity provoke psychological trauma associated with the rough defloration, attempt to rape, fear of pregnancy or publicity relations, physical aversion to the partner, excessive fixation on the absence of orgasm, and depression. Anorgasmia (no orgasm) is most often manifestation of frigidity caused by disharmony of sexual relations. Is the result of premature ejaculation from her husband, an interrupted sexual intercourse, lack of psycho erotic training women to converge incorrectly selected poses. Symptoms range from reducing the sensation of brightness to full frigidity. Vaginismus is twitching vagina and pelvic day, preventing the carrying out of sexual intercourse.

We have used new methods of recovery of potency, erections, increase the frequency and duration of sexual acts that have a restorative, normalizing effect on the genitourinary, central and peripheral nervous, cardiovascular, endocrine system. We use new high-performance methods of treatment of impotence, of all types of prostatitis, erectile dysfunction (psychogenic, vascular, neurogenic, endocrine, drug, diabetes), early and delayed ejaculation, neurosis, anxious expectation of failure, reduced sex drive, set a businessman, manager of the syndrome, Gamers syndrome, sexual abstinence, postcoital headaches, orgasmic anhedonia, postcoital dysphoria, male infertility. Methods of impact on the causes and mechanisms of disease development can achieve high treatment efficiency at any age. You can also use Abra to help potency problems at home. Using Abra doesn’t require any special skills.

Combined treatment of female sexual dysfunction (anorgasmia, vaginismus, genitalgii, dyspareunia, nymphomania, sexual hysteria, virgogamiya, pathological menopause, etc.) aimed at creating optimal conditions for the manifestation of female sexuality, the normalization parameters of sexual intercourse. Also, we are restoring sexual function in men and women after exposure to adverse pathological factors (the effects of smoking, alcohol, electromagnetic radiation, radiation, vibration, driving, etc.) and in various diseases (diabetes, scleroderma, Peyronie's disease, menopausal syndrome, schizophrenia , epilepsy, hypertension, coronary heart disease, atherosclerosis, pelvic trauma, diseases of the nervous system, etc.).